MPSD Seminar

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Ming Lei - Capping the Ends: Structure and Function of Telomere Proteins

  • Date: Jul 3, 2017
  • Time: 16:00 - 17:00
  • Speaker: Ming Lei
  • National Center for Protein Science | Shanghai
  • Location: CFEL (Bldg. 99)
  • Room: Seminar Room IV, O1.111
  • Host: R. J. Dwayne Miller
Telomeres, the natural ends of linear eukaryotic chromosomes, are specialized protein-DNA complexes that play essential roles in cell viability and genome integrity. The long-term goal of my research is to understand how telomeres protect chromosome ends and mediate their replication by telomerase. A six-protein complex, called shelterin, associates with telomeres and protects the ends of human chromosomes. A major gap in our knowledge of the shelterin complex is how its protein components organize at telomeres. I will present our recent studies that reveal the molecular architecture and functional significance of the shelterin complex.
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