The conformational dynamics of a protein are often essential for its function. In this talk I will present how time-resolved X-ray scattering and vibrational spectroscopy can be used to investigate protein dynamics based on two examples: the light sensing protein phytochrome and green fluorescent protein. In particular, I will show how computational chemistry can support the design and analysis of these experiments and how Molecular dynamics simulations can be used to predict the structural stability of small cyclic peptides.
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