Archive 2017

Here you can find past events of the MPSD institute.

Room: Seminar Room IV, O1.111 Host: R. J. Dwayne Miller

Thomas Renger - Structure-based theory of light-harvesting in photosynthesis

MPSD ARD Seminar
Two challenges in the simulation of excitation energy transfer and optical spectra of pigment-protein complexes are the equal magnitude of the excitonic and the exciton-vibrational coupling and the structure-based parametrization of the Hamiltonian (for review see ref. 1). We have developed quantum chemical/electrostatics/normal mode analysis (NMA) schemes to calculate optical transition energies of pigments in their binding site in the protein (site energies), interpigment excitonic couplings and the spectral density of the pigment-protein coupling. Our NMA of the spectral density shows that the modulation of site energies is an order of magnitude stronger than that of the excitonic couplings and that also in the basis of delocalized exciton states the diagonal exciton-vibrational coupling dominates [2]. This result explains the good performance of our earlier time-local lineshape theory [3], in which the diagonal elements are treated exactly and the off-diagonal elements in Markov and secular approximations, and triggered a new development that takes into account the finite relaxation time of nuclei during exciton relaxation [4]. I will give a summary of our theory development and present applications on a small model system (water soluble chlorophyll binding protein -WSCP) and large photosystem II core particles. In the case of WSCP we have developed and applied a theory of holeburning spectroscopy [5] that goes beyond the standard two-level system approach and allows for a quantitative description of experimental data, revealing the lifetime of the upper exciton state, in excellent agreement with results from 2D electronic spectroscopy and our earlier prediction [6]. In the case of photosystem II I will present results of the parametrization of the exciton Hamiltonian of its subunits [7-9]. These parameters were used to describe VIS/IR pump-probe data on single crystals of PSII core particles [10] that allowed for a verification of our earlier prediction [11] on the relative timescale of excitation energy and charge transfer in this system. The results are discussed in terms of photoprotection scenarios that allow photosystem II to switch between a light harvesting and an excitation energy quenching mode protecting the reaction center. [more]

Ming Lei - Capping the Ends: Structure and Function of Telomere Proteins

MPSD Seminar
Telomeres, the natural ends of linear eukaryotic chromosomes, are specialized protein-DNA complexes that play essential roles in cell viability and genome integrity. The long-term goal of my research is to understand how telomeres protect chromosome ends and mediate their replication by telomerase. A six-protein complex, called shelterin, associates with telomeres and protects the ends of human chromosomes. A major gap in our knowledge of the shelterin complex is how its protein components organize at telomeres. I will present our recent studies that reveal the molecular architecture and functional significance of the shelterin complex. [more]
Go to Editor View