MPSD Publications

Publications of E.-C. Schulz

Journal Article (12)

2021
Journal Article
A simple vapor-diffusion method enables protein crystallization inside the HARE serial crystallography chip
B. Norton-Baker, P. Mehrabi, J. Boger, R. Schönherr, D. von Stetten, H. Schikora, A. O. Kwok, R. W. Martin, R. J. D. Miller, L. Redecke, E.-C. Schulz
Acta Crystallographica Section D: Structural Biology 77 (6), D77 (2021)
Journal Article
X-ray screening identifies active site and allosteric inhibitors of SARS-CoV-2 main protease
S. Günther, P. Y. A. Reinke, Y. Fernández-García, J. Lieske, T. J. Lane, H. M. Ginn, F. H. M. Koua, C. Ehrt, W. Ewert, D. Oberthuer, O. Yefanov, S. Meier, K. Lorenzen, B. Krichel, J.-D. Kopicki, L. Gelisio, W. Brehm, I. Dunkel, B. Seychell, H. Gieseler, B. Norton-Baker, B. Escudero-Pérez, M. Domaracky, S. Saouane, A. Tolstikova, T. A. White, A. Hänle, M. Groessler, H. Fleckenstein, F. Trost, M. Galchenkova, Y. Gevorkov, C. Li, S. Awel, A. Peck, M. Barthelmess, F. Schlünzen, L. X. Paulraj, N. Werner, H. Andaleeb, N. Ullah, S. Falke, V. Srinivasan, B. A. Franca, M. Schwinzer, H. Brognaro, C. Rogers, D. Melo, J. J. Zaitsev-Doyle, J. Knoska, G. E. P. Murillo, A. R. Mashhour, F. Guicking, V. Hennicke, P. Fischer, J. Hakanpää, J. Meyer, P. Gribbon, B. Ellinger, M. Kuzikov, M. Wolf, A. R. Beccari, G. Bourenkov, D. von Stetten, G. Pompidor, I. Bento, S. Panneerselvam, I. Karpics, T. R. Schneider, M. M. G. Alai, S. Niebling, C. Günther, C. Schmidt, R. Schubert, H. Han, J. Boger, D. C. F. Monteiro, L. Zhang, X. Sun, J. Pletzer-Zelgert, J. Wollenhaupt, C. G. Feiler, M. S. Weiss, E.-C. Schulz, P. Mehrabi, K. Karničar, A. Usenik, J. Loboda, H. Tidow, A. Chari, R. Hilgenfeld, C. Uetrecht, R. Cox, A. Zaliani, T. Beck, M. Rarey, S. Günther, D. Turk, W. Hinrichs, H. N. Chapman, A. .R. Pearson, C. Betzel, A. Meents
Science 372 (6542), 642–646 (2021)
Journal Article
Serial femtosecond and serial synchrotron crystallography can yield data of equivalent quality: A systematic comparison
P. Mehrabi, R. Bücker, G. Bourenkov, H. Ginn, D. von Stetten, H. M. Mueller-Werkmeister, A. Kuo, T. Morizumi, B. Eger, W.-L. Ou, S. Oghbaey, A. Sarracini, J. Besaw, O. Paré-Labrosse, S. Meier, H. Schikora, F. Tellkamp, A. Marx, D. A. Sherrell, D. Axford, R. L. Owen, O. P. Ernst, E. F. Pai, E.-C. Schulz, R. J. D. Miller
Science Advances 7 (12), eabf1380 (2021)
Journal Article
Environmental Liquid Cell Technique for Improved Electron Microscopic Imaging of Soft Matter in Solution
S. Azim, L. Bultema, M. de Kock, E. R. Osorio-Blanco, M. Calderón, J. Gonschior, J.-P. Leimkohl, F. Tellkamp, R. Bücker, E.-C. Schulz, S. Keskin, N. de Jonge, G. Kassier, R. J. D. Miller
Microscopy and Microanalysis 27 (1), 44–53 (2021)
2020
Journal Article
The crystal structure of mycobacterial epoxide hydrolase A
E.-C. Schulz, S. R. Henderson, B. Illarionov, T. Crosskey, S. M. Southall, B. Krichel, C. Uetrecht, M. Fischer, M. Wilmanns
Scientific Reports 10 (1), 16539 (2020)
Journal Article
The HARE chip for efficient time-resolved serial synchrotron crystallography
P. Mehrabi, H. Müller-Werkmeister, J.-P. Leimkohl, H. Schikora, J. Ninkovic, S. Krivokuca, L. Andriček, S. W. Epp, D. Sherrell, R. L. Owen, A. R. Pearson, F. Tellkamp, E.-C. Schulz, R. J. D. Miller
Journal of Synchrotron Radiation; Wiley-Blackwell on Behalf of the IUCr 27 (2), 360–370 (2020)
Journal Article
Serial protein crystallography in an electron microscope
R. Bücker, P. Hogan-Lamarre, P. Mehrabi, E.-C. Schulz, L. Bultema, Y. Gevorkov, W. Brehm, O. Yefanov, D. Oberthür, G. Kassier, R. J. D. Miller
Nature Communications 11 (1), 996 (2020)
2019
Journal Article
Liquid application method for time-resolved analyses by serial synchrotron crystallography
P. Mehrabi, E.-C. Schulz, M. Agthe, S. Horrell, G. Bourenkov, D. von Stetten, J.-P. Leimkohl, H. Schikora, T. R. Schneider, A. R. Pearson, F. Tellkamp, R. J. D. Miller
Nature Methods 16 (10), 979–982 (2019)
Journal Article
Time-resolved crystallography reveals allosteric communication aligned with molecular breathing
Science 365 (6458), 1167–1170 (2019)
2018
Journal Article
The hit-and-return system enables efficient time-resolved serial synchrotron crystallography
E.-C. Schulz, P. Mehrabi, H. Müller-Werkmeister, F. Tellkamp, A. Jha, W. Stuart, E. Persch, R. De Gasparo, F. Diederich, E. F. Pai, R. J. D. Miller
Nature Methods 15 (11), 901–904 (2018)
2017
Journal Article
Protein crystals IR laser ablated from aqueous solution at high speed retain their diffractive properties: applications in high-speed serial crystallography
Journal of Applied Crystallography 50, 1773–1781 (2017)
Journal Article
Low-dose fixed-target serial synchrotron crystallography
R. L. Owen, D. Axford, D. A. Sherrell, A. Kuo, O. P. Ernst, E.-C. Schulz, R. J. D. Miller, H. Müller-Werkmeister
Acta Crystallographica Section D: Structural Biology 73, 373–378 (2017)

Conference Paper (2)

2018
Conference Paper
Time-resolved crystallography via an interlacing approach allows elucidation of milliseconds to seconds time delays
P. Mehrabi, E.-C. Schulz, H. M. Müller-Werkmeister, E. Persch, R. D. Gasparo, F. Diederich, F. Tellkamp, E. Pai, R. J. D. Miller
Acta Crystallographica Section A: Foundations and Advances, vol. 74, IUCr/Wiley; 2018, p. e138–e138
2017
Conference Paper
Serial Synchrotron Cryallography with a Fixed Target
H. Müller-Werkmeister, E.-C. Schulz, D. Sherrell, D. Axford, F. Tellkamp, R. L. Owen, R. J. D. Miller
Biophysical Journal, vol. 112. 3rd ed., Cambridge, Mass.: Cell Press; 2017, p. 579A–579A

Working Paper (1)

2020
Working Paper
Catalytic cleavage of HEAT and subsequent covalent binding of the tetralone moiety by the SARS-CoV-2 main protease
S. Günther, P. Y. A. Reinke, D. Oberthuer, O. Yefanov, H. Ginn, S. Meier, T. J. Lane, K. Lorenzen, L. Gelisio, W. Brehm, I. Dunkel, M. Domaracky, S. Saouane, J. Lieske, C. Ehrt, F. Koua, A. Tolstikova, T. A. White, M. Groessler, H. Fleckenstein, F. Trost, M. Galchenkova, Y. Gevorkov, C. Li, S. Awel, A. Peck, L. X. Paulraj, M. Barthelmess, F. Schlünzen, N. Werner, H. Andaleeb, N. Ullah, S. Falke, B. A. Franca, M. Schwinzer, H. Brognaro, B. Seychell, H. Gieseler, D. Melo, J. J. Zaitsev-Doyle, B. Norton-Baker, J. Knoska, G. Esperanza, A. R. Mashhour, F. Guicking, V. Hennicke, P. Fischer, C. Rogers, D. C. F. Monteiro, J. Hakanpää, J. Meyer, H. Noei, P. Gribbon, B. Ellinger, M. Kuzikov, M. Wolf, L. Zhang, X. Sun, J. Pletzer-Zelgert, J. Wollenhaupt, C. Feiler, M. Weiss, E.-C. Schulz, P. Mehrabi, C. Schmidt, R. Schubert, H. Han, B. Krichel, Y. Fernández-García, B. Escudero-Pérez, S. Günther, D. Turk, C. Uetrecht, T. Beck, H. Tidow, A. Chari, A. Zaliani, M. Rarey, R. Cox, R. Hilgenfeld, H. N. Chapman, A. R. Pearson, C. Betzel, A. Meents
(2020)
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